- Chief Investigator Malaria Vaccine Clinical Trials
- Research Fellow Wolfson College
- Honorary Consultant in Infectious Diseases (Oxford University Hospitals NHS Foundation Trust)
- Vice-Chair Graduate Studies Committee (Medical Sciences Division)
I am an infectious diseases physician by training and lead a clinical malaria vaccine programme at the University of Oxford. This involves testing first-time-in-human vaccines against Plasmodium falciparum and Plasmodium vivax, incorporating controlled human malaria infection to test vaccine efficacy.
I am passionate about building relationships and transferring skills to empower the research teams where malaria is endemic, and our trials now span Phase 1/2 in the UK and across East and West Africa. I also currently co-lead the EDCTP3-funded 2nd-Generation Malaria Vaccine Consortium (MVC-2G).
Using the platform of the malaria human challenge model I also conduct experimental medicine research to explore mechanisms of disease tolerance, and am developing a novel model of relapse for Plasmodium vivax. I have also run clinical trials of vaccines against emerging pathogens and have an interest in developing new human challenge models of infection with which to assess new vaccines.
